This could be the result of basic processes such as habituation or sensory adaptation, at the receptor level. A protective effect of the genetic variant sickle cell trait against malaria has been well documented. However, few studies have assessed whether HbAS may be protective against other conditions. COMT has been studied intensively in relation to several reward-motivated behaviours such as development of diet-induced obesity. It is known that the G-allele of COMT rs4680 is associated with low COMT activity of soluble COMT, thus conferring slow detoxification of neurotransmitters such as the degradation and inactivation of dopamine. We found an association between COMT 24938A/G and fat-BMI, and borderline with waist circumference, which is in accordance with the suggested role of COMT polymorphisms in obesity and in line with results from a recently published population-based study showing an association between COMT 24938A/G and body fat distribution measured as waist-hip ratio. This is understandable since endotoxin has been EX 527 reported to be detrimental to hepatocyte and steroid has been believed to lead to elevated lipogenesis and then overburden of lipid transportation of hepatocyte. Further, ALT or AST did not significantly change from baseline when compared to the CON group among the three dosage groups, indicating hepatic safety of EF. Having Grade 3 hypertension was associated with a significantly increased odds of developing target organ damage and there was a significant trend observed between increasing severity of hypertension and the odds of developing target organ damage. These findings emphasize the importance of instituting intervention programs on hypertension among civil servants which do not only focus on the primary prevention, early detection and treatment of hypertension, but also on the importance of lowering BP among those with hypertension. Importantly, severe hypertension should be prevented. Adequate therapy needed to achieve the goal blood pressure must be initiated and continued. Studies have shown that when a given mutation is found in different species it has varying effects based on the comparative rate of ROS leakage in the species. The threshold of ROS signal needed for the cell to commit apoptosis depends on the rate at which ROS are produced from the mitochondria. Intuition might suggest that the threshold of ROS signal needed for the cell to commit to apoptosis is static. However, it appears to be dependent upon the rate of ROS production from the mitochondria, exhibiting a tight correlation between mutations and a ROSsignal apoptotic threshold. Whether the role of free radicals in aging and longevity involves the toxicity of ROS over time or the important signaling role of ROS in programmed cell death, it is important that studies of longevity turn attention toward mechanisms by which ROS is produced in the respiratory.