The enrichment of transcription factors belonging to Myb, ERF, NAC, bHLH, NY-YA, and C2H2 transcription factor family proteins in GRF1 or GRF3 potential direct target genes suggests key roles of these transcription factors in initiating transcriptional cascades, thereby extending the effects of GRF1 or GRF3 on downstream signaling pathways. Transcription factors can positively or negatively regulate the expression of their target genes. Our data point to the possibility that GRF1/3 may function as transcriptional repressors since more than half of the GRF1/3 targets are negatively regulated. Initially, members of the GRF gene family have been shown to function as transcriptional activators and this transactivation function involves the C-terminal region. More recently, GRF7 was found to function as transcriptional repressor through Polyphyllin-VII its N-terminal QLQ and WRC motifs. Rabbits have the same lipid metabolism as human as opposed to mice that express APOBEC1 gene both in the liver and intestine, do not have CETP and have higher level of HDL and lower level of LDL, that altogether makes mice a less suitable model to study lipid metabolism than rabbits. Thus, we generated transgenic rabbits by knocking down the endogenous APOBEC1 gene using RNA interference strategy and expressing permanently a small hairpin RNA targeting specifically the rabbit APOBEC1 mRNA. We generated also transgenic rabbits expressing the human APOBEC1 gene,Pseudoprotodioscin and double transgenic animals by inter-crossing these two models. We observed interesting differences in the phenotypes of these rabbits, especially as regard to their body weight and total lipid content. Finally, our results suggest that APOBEC1 could be considered as a potential target for metabolic disorder treatment. One copy of integrated transgene was integrated in each line. In the rabbit species, this phenomenon is responsible for the conversion of a C residue in a U one at the 2177th codon of the rabbit APOB mRNA. We have attempted to quantify the level of editing in the various transgenic lines and in wild type animals to test whether the reduction of APOBEC1 gene expression could modify the APOB mRNA editing.