Consistent with these observations, our studies demonstrated that Stattic sensitize the NPC to radiotherapy. By targeting multiple oncogenic signaling pathways, Stattic may be able to sensitize tumors to radiotherapy and chemotherapy. Our finding suggests that a combination of Stattic with cisplatin or radiotherapy may be more effective in treating cancer patients than either drug alone. These results provide supportive evidence that Stattic may be effective in suppressing NPC tumor cell growth in cancer patients with constitutive Stat3 signaling. In addition to Stattic, several other small molecule inhibitors of STAT3 have been described in the literature, and continuing efforts to develop more potent STAT3 inhibitors are under way. In particular, STA-21 and S3I-201 selectively target the DNA-binding domain of STAT3 and effectively suppress its activity in rhabdomyosarcoma, osteosarcoma, and breast cancer. This new generation of small molecule inhibitors is based on virtual screening of the crystalline structure of STAT3 and has offered promising results. Given the role of STAT3 in modulating tumor viability, radiosensitivity, and chemosensitivity, the development of an efficient STAT3 inhibitor is critical in the development of novel treatment regimens for solid tumors. Our findings emphasize the importance of Stattic in tumor viability and resistance to chemotherapy and radiotherapy. Having demonstrated a valuable therapeutic strategy involving STAT3 inhibition in NPC, this work should provide impetus for the clinical evaluation of biological modifiers that may enhance cisplatin treatment and radiotherapy and potentially reduce undesirable side effects associated with currently available treatment strategies. The mechanical properties of plant cell walls are remarkable because they must be flexible and deformable to allow morphogenesis and cell expansion, whilst providing structural integrity and rigidity to the plant. These properties are also of interest in providing inspiration and design rules for the construction of cellulose-based structuring materials for diverse technological uses. The role of specific polysaccharide components in the micromechanical behaviour of plant cell walls is not fully established. The current proposed structural model for the primary plant cell wall describes the wall of dicotyledons and non-commelinid monocotyledons as a complex network of cellulose microfibrils and hemicelluloses embedded in a pectin gel network. The major set of non-cellulosic polysaccharides in the primary cell walls of cereals, grasses and related commelinid species are the heteroxylans, Paclitaxel consisting of linear chains of ��- 1,4-linked D-xylose, which in the case of arabinoxylan, are substituted by arabinose on the C-2 and/or C-3 position and can also carry other substituents such as glucuronic acid. The structural roles of hemicelluloses in the cell wall are not fully CP-358774 established but are considered to include the tethering of cellulose fibres so as to restrict the ability of fibres to separate laterally. Based on chemical extractability and enzyme accessibility, xyloglucan for example is considered to have three domains in the cell wall; one domain crosslinks or is otherwise between cellulose microfibrils, while another domain binds to the surface of cellulose fibres, and a third domain is entrapped between cellulose microfibrils inside cellulose fibres.