Over time, the most represented Estazolam categories of papers included diagnostic/epizootiology, host �C parasite interactions, and cell biology. The large numbers of diagnostic/epizootiology studies can be attributed to the increasing number of countries performing surveys as a result of current concerns about Dermo disease associated to the increase in worldwide trade of bivalve species. The increase in publications on host �C parasite 5HPP-33 interactions and cell biology of the parasite suggests that more research groups are focusing on the mechanistic aspects of the parasitic disease. At a lesser scale, the development of methods for purification of Bonamia cells, also has favored several mechanistic studies. Similarly, the identification of a probable intermediate host in the life cycle for Marteilia refringens, appears to be responsible for the noticeable increase in publications during 2013. It would be expected that the sequencing of the genomes of protozoan parasites would significantly increase not only the publication rates, but also the number of mechanistic studies. Surprisingly, the publication of the genomes of Plasmodium falciparum and Cryptosporidium spp. ) did not result in the expected increase in the total number of papers published per year ; instead, both Plasmodium and Cryptosporidium species are highly autocorrelated out to.20 years, indicating that the amount of papers in any given year is strongly connected to the number of papers in previous years. Both time series have an underlying periodicity of 20�C30 years, though for P. falciparum, the dominant period is the full length of the time series. This trend is perhaps the result of the continued high publication rates for these two particular parasite species during the past decade and the fact that the full length sequences for numerous genes had been available much earlier than their genome drafts. It remains to be seen in the next few years if the availability of genome sequences for parasites from bivalve molluscs, obviously less popular than Plasmodium and Cryptosporidium, will significantly change the publication rates, particularly on mechanistic studies that may lead to the identification of therapeutic or ecological targets and the development of new intervention strategies against the disease to complement available strategies.