The dissection of the ��switch�� of miRSNPs on miRNAs�� regulation on relevant pathways would help to elucidate their potential roles in MG pathogenesis both as genetic variants and at the post-transcriptional regulation level. In this study, we have for the first time, systematically identified candidate functional miRSNPs and their potential mechanisms based on the current genetic findings of MG. Through manually compiling the MG risk gene catalog, we enriched MG risk pathways, and then identified miRNAs targeting MG risk pathways. Furthermore, we revealed the candidate functional miRSNPs ��switches�� in the miRNAs that regulate MG risk pathways by searching and screening reliable miRSNPs database information, and constructed the MSSPN. In addition, we carried out an in-depth dissection of the correlation with hsa05200, elaborated the significance of four high-risk genes, and proposed the potential mechanisms of Buflomedil HCl particular miRSNPs as ��switches�� in miRNAs regulation of the MG risk pathways. The 18 MG risk pathways we identified provides an overview of MG pathogenesis and reflects the macroscopic effect of dysfunctions in MG risk genes and gene modulators. They may also reveal the latent relationship between MG and other disorders, for example, ��hsa05330 �� was revealed to have the most significant relationship with MG at a biological pathway level, which was in consistent with several case-reports of MG arising after allogeneic bone marrow transplantation or as a manifestation of chronic graft-versus-host-disease. Another potential advantage of our pathway analysis approach is that it may provide insights into identification of disease subtypes. MG is heterogeneous in its clinical manifestations. Pathway-based genetic analyses may help identify different, and even unrelated, biological mechanisms as responsible for similar disease pathogenesis. The implications of such potential discovery are broad, because it might lead to Ambroxol targeted therapeutics and individual treatment.Here, we found a close link between MG and cancer in the pathway view, supporting the notion of paraneoplastic MG, meaning the pathogenesis of MG is highly related with neoplasms, as another important subtype of MG.