Importantly, the cmb mutation suppresses the MHC phenotype of mwh in double mutants. Our data thus indicate that Cmb, while not essential for wing hair formation, nevertheless promotes trichome formation in vivo. Hematopoiesis is a complex and dynamic process, which generates mature blood cells throughout the life of organisms. In the adult bone marrow, long-term hematopoietic stem cells maintain a balanced pool of stem cells, which also differentiates into more mature short-term hematopoietic stem cells, multipotent progenitors with a lower self-renewal capacity. It is believed that the blood lineage choice of HSCs is governed by a stepwise cell fate decision. However, recent studies have raised questions about the hierarchical hematopoietic system. Many studies based on genome-wide gene expression profiling have demonstrated that specific extrinsic and intrinsic regulators play key roles in hematopoiesis. Recently, high-throughput sequencing Optovin techniques have been applied widely, which have provided new insights into in vivo transcription factor Thioridazine hydrochloride binding and epigenetic modifications. Systems biology approaches are also enhancing our understanding of the regulatory dynamics of hematopoiesis. Despite the biological importance of the formation of all blood cells via a transition from LT-HSC to ST-HSC, little is known about the mechanism that underlies this early differentiation. A major explanation for this deficiency is a lack of comprehensive genome-wide identification studies and characterizations of the regulatory elements that govern gene expression in HSCs. The profiling of potential key regulators and the large-scale integration of datasets have improved our understanding greatly. However, these studies are limited to a small number of factors that function in heterogeneous HSCs, which were isolated using different combinations of monoclonal antibodies. Therefore, unconsidered key regulators may exist at this early stage of hematopoiesis. Indeed, novel key factors and new multipotent progenitors have been identified recently.