Although there were very few reports regarding whether a cross-reaction exists between silkworm moth and mites, intra- and interspecies cross-reactivities among allergens from mites and cockroaches have been widely recognized. A previous immunochemical study has reported cross-reactivity existing between house dust mites and snails, crustaceans, cockroaches, chironomids, and other mite allergens. In the majority of related studies, house dust mite extracts proved to be a powerful inhibitor for the cross-inhibition tests, suggesting that it is the main Isoacteoside source of many allergens resulting in 
hypersensitivity. Our findings provide serum sIgE data showing that silkworm moth is an important allergen for respiratory allergies in the region and a positive correlation exists between silkworm moth and the relevant mites and cockroaches. We acknowledge that owing to the retrospective nature of the study, we cannot conclude on the cross-reaction between these allergens. Further serum inhibition studies are warranted to verify such relationship, and if so, it would be worthwhile to find out whether it is a ributed to arginine kinase. Features of Ursolic-acid diabetic retinopathy are retinal microaneurysms, retinal hemorrhages, retinal edema, retinal vein dilatation, and lipid deposition in the deep retinal layers. Since leakage of lipids, erythrocytes and serum through a vessel wall depends on the pressure in the vessel, since the diameter of a vessel also depends on its internal pressure, and since capillary blood pressure is influenced by the pressure in the draining veins, we assumed that an increased retinal vein pressure is a factor associated with presence and severity diabetic retinopathy. The blood pressure in the central retinal vein inside of the eye is at least as high as the orbital cerebrospinal fluid pressure, since the central retinal vein passes, after leaving the eye, through the optic nerve and the orbital cerebrospinal fluid space. We therefore put forward the hypothesis that an increased CSFP is associated with diabetic retinopathy. This hypothesis would fit with the role of arterial hypertension as risk factor for diabetic retinopathy, since a higher arterial blood pressure is associated with a higher CSFP. To test the hypothesis, we conducted a study in which we estimated the CSFP and compared eyes with diabetic retinopathy and eyes without diabetic retinopathy. In previous studies, the correlation between CSFP and age, arterial blood pressure and body mass index was described and a formula allowed estimating the CSFP. We used this formula to assess the CSFP in the participants of our study. We chose a population-based study design to avoid a referral induced bias in the selection of study participants. For all study participants, an interview was performed with standardized questions on the level of education, quality of life, known major systemic diseases, and other parameters. Fasting blood samples were taken for measurement of blood lipids, glucose and glycosylated hemoglobin HbA1c. Body height and weight and the circumference of the waist and hip were measured. The blood pressure was measured with the participant si ing for at least 5 minutes.